HLA-DQB1, -DQA1, -DPB1, and -DPA1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 1064 individuals
| Autor: | Janette Kwok, Ching-Pang Lee, Wanling Yang, Derek Middleton, WH Tang, W.K. Chu, Zhongyi Liu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male endocrine system diseases Genotyping Techniques Immunology Population Biology HLA-DP alpha-Chains HLA-DQ alpha-Chains 03 medical and health sciences 0302 clinical medicine Gene Frequency Immunology and Allergy HLA-DQ beta-Chains Humans Allele education Allele frequency Genotyping HLA-DP beta-Chains education.field_of_study HLA-DQB1 Haplotype General Medicine Transplantation 030104 developmental biology Haplotypes Hong Kong Female 030215 immunology Demography HLA-DRB1 Chains |
| Zdroj: | Human immunology. 81(1) |
| ISSN: | 1879-1166 |
| Popis: | HLA-DQB1, -DQA1, -DPB1, and -DPA1 genotyping and haplotype frequencies have been calculated from 1064 southern Chinese unrelated donors in a Hong Kong Bone Marrow Donor Registry. This is the first paper to report the distribution of DQB1-DQA1 and DPB1-DPA1 alleles in Hong Kong Chinese. Due to the Hardy-Weinberg equilibrium proportions (HWEP) deviation in DPB1 loci, this information may be of limited use for phylogenetic, comparative studies but will be useful for the permissible matching in HLA-DPB1 for Chinese patients awaiting haematopoietic stem cell transplantation in the near future due to the new recommendation of NMDP matching guidelines. The allele and haplotype data are available in the Allele Frequencies Net Database under the population name ''Hong Kong Chinese HKBMDR, DQ and DP'' and the identifier (AFND3667). |
| Databáze: | OpenAIRE |
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