Case series of HIV SARS-CoV-2 co-infection in Chinese adults
| Autor: | Rita Wai-Yin Ng, Chun-Kwok Wong, Grace Chung-Yan Lui, Eugene Yuk-Keung Tso, Zigui Chen, Owen Tak-Yin Tsang, Siaw Shi Boon, Christopher Koon-Chi Lai, Kitty Sau-Chun Fung, Apple Chung-Man Yeung, Wendy Ching-Sze Ho, David Shu-Cheong Hui, Paul Kay-Sheung Chan, Jacky Man-Chun Chan |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Clinical Virology plus Journal of Clinical Virology Plus, Vol 2, Iss 1, Pp 100062-(2022) |
| ISSN: | 2667-0380 |
| Popis: | Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong. Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed. Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset. Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10. |
| Databáze: | OpenAIRE |
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