Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate

Autor:	Jing-Yi Wang, Frank Streckenbach, Xiao-Qi Yu, Yufen Zhao, Ji Zhang, Da-Wei Zhang, Yan Liu, Jun-Liang Liu, Hong-Hui Lin, Zhuo Tang, Ming-Qi Wang
Rok vydání:	2011
Předmět:	Models Molecular Peptide Nucleic Acids Cyclams Catalysis Substrate Specificity chemistry.chemical_compound Hydrolysis Nucleic acid thermodynamics Cyclen Heterocyclic Compounds Materials Chemistry Site selective Organic chemistry DNA Cleavage Nucleic acid analogue Binding Sites Peptide nucleic acid Metals and Alloys General Chemistry DNA Combinatorial chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Ceramics and Composites Nucleic Acid Conformation Conjugate
Zdroj:	Chemical communications (Cambridge, England). 47(39)
ISSN:	1364-548X
Popis:	A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0146e17d5970083c27e06a963cfec04c https://pubmed.ncbi.nlm.nih.gov/21901188 Zobrazit plný text záznamu