Metabolomic differences of exhaled breath condensate among children with and without asthma
| Autor: | Hung-Yao Ho, Ju Chang-Chien, Wan-Chen Lin, Tsung-Chieh Yao, Shih-Ling Wang, Chi-Jen Lo, Hsin-Yi Huang, Mei-Ling Cheng, Hui Ju Tsai, Yu-Lun Tseng |
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| Rok vydání: | 2020 |
| Předmět: |
Spirometry
medicine.medical_specialty Immunology Population Nitric Oxide FEV1/FVC ratio Metabolomics Internal medicine medicine Humans Immunology and Allergy Exhaled breath condensate Child education Asthma education.field_of_study medicine.diagnostic_test Receiver operating characteristic business.industry medicine.disease respiratory tract diseases Breath Tests Exhalation Pediatrics Perinatology and Child Health Cohort business Biomarkers |
| Zdroj: | Pediatric Allergy and Immunology. 32:264-272 |
| ISSN: | 1399-3038 0905-6157 |
| DOI: | 10.1111/pai.13368 |
| Popis: | BACKGROUND There remains an unmet need in objective tests for diagnosing asthma in children. The objective of this study was to investigate the potential of metabolomic profiles of exhaled breath condensate (EBC) to discriminate stable asthma in Asian children in the community. METHODS One hundred and sixty-five Asian children (92 stable asthma and 73 non-asthmatic controls) participating in a population-based cohort were enrolled and divided into training and validation sets. Nuclear magnetic resonance-based metabolomic profiles of EBC samples were analyzed by using orthogonal partial least squares discriminant analysis. RESULTS EBC metabolomic signature (lactate, formate, butyrate, and isobutyrate) had an area under the receiver operator characteristic curve (AUC) of 0.826 in discriminating children with and without asthma in the training set, which significantly outperformed FeNO (AUC = 0.574; P |
| Databáze: | OpenAIRE |
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