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Summary The blood of a normal 38-year-old Japanese woman, Mrs. N. exhibited an unusual property in that (1) her red cells were inagglutinable or agglutinable very weakly by various anti-B sera, (2) her cells failed to react with ordinary anti-H reagents, (3) a trace of anti-H was found in the serum, but (4) she secreted both B and H substances in her saliva. Her husband was group O and three of her children were normal group B and one was group O. To explain this finding, we propose the presence of a new, rare, modifying gene ‘w’ which suppresses, in the double dose, B and H substances in the cells without any effect on the secretor system. |
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