Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis
| Autor: | John Richert, Ayse Altintas, Diego Franciotta, Florian Deisenhammer, Michael Khalil, Steven G. Hughes, Matilde Degn, Ales Bartos, Bernhard Hemmer, José C. Álvarez-Cermeño, Antonio Bertolotto, Frode S. Berven, Hayrettin Tumani, Jette L. Frederiksen, Harald Hegen, Lou Brundin, Ann Cathrine Kroksveen, Irena Dujmovic, Rogier Q. Hintzen, Jelena Drulovic, Jens Kuhle, Sharmilee Gnanapavan, Ellen Iacobaeus, Daniela Galimberti, Franz Fazekas, Luisa M. Villar, Til Menge, Charlotte E. Teunissen, Manuel Comabella |
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| Přispěvatelé: | Neurology, Laboratory Medicine, NCA - Neuroinflamation |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Consensus Multiple Sclerosis Disease 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine Terminology as Topic Medicine Diagnostic biomarker Humans 030304 developmental biology 0303 health sciences business.industry Multiple sclerosis Clinical study design Patient Selection Spinal anesthesia medicine.disease Control Groups 3. Good health ddc Neurology Research Design Immunology Csf biomarkers Biomarker (medicine) Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Teunissen, C, Menge, T, Altintas, A, Alvarez-Cermeno, J C, Bertolotto, A, Berven, F S, Brundin, L, Comabella, M, Degn, M, Deisenhammer, F, Fazekas, F, Franciotta, D, Frederiksen, J L, Galimberti, D, Gnanapavan, S, Hegen, H, Hemmer, B, Hintzen, R, Hughes, S, Iacobaeus, E, Kroksveen, A C, Kuhle, J, Richert, J, Tumani, H, Villar, L M, Drulovic, J, Dujmovic, I, Khalil, M & Bartos, A 2013, ' Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis ', Multiple Sclerosis, vol. 19, no. 13, pp. 1802-1809 . https://doi.org/10.1177/1352458513488232 Multiple Sclerosis, 19(13), 1802-1809. SAGE Publications Ltd |
| ISSN: | 1352-4585 |
| Popis: | The choice of appropriate control group(s) is critical in cerebrospinal fluid (CSF) biomarker research in multiple sclerosis (MS). There is a lack of definitions and nomenclature of different control groups and a rationalized application of different control groups. We here propose consensus definitions and nomenclature for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease controls (INDCs), peripheral inflammatory neurological disease controls (PINDCs), non-inflammatory neurological controls (NINDCs), symptomatic controls (SCs). Furthermore, we discuss the application of these control groups in specific study designs, such as for diagnostic biomarker studies, prognostic biomarker studies and therapeutic response studies. Application of these uniform definitions will lead to better comparability of biomarker studies and optimal use of available resources. This will lead to improved quality of CSF biomarker research in MS and related disorders. |
| Databáze: | OpenAIRE |
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