X-linked hypophosphatemia: effects of treatment with recombinant human growth hormone
| Autor: | Gusztáv Stubnya, Tivadar Tulassay, Gabriel Miltényi, György Reusz, Dennis J. Byrd, András Szabó, Csaba Horváth, Ferenc Péter |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty X Chromosome Bone density Bone disease Genetic Linkage Growth Phosphates Bone Density Internal medicine medicine Vitamin D and neurology Humans Child Hypophosphatemia Familial Bone mineral business.industry medicine.disease X-linked hypophosphatemia Body Height Familial Hypophosphatemic Rickets Hypophosphatemic Rickets Endocrinology Nephrology Growth Hormone Pediatrics Perinatology and Child Health Calcium Female business Hypophosphatemia |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 11(5) |
| ISSN: | 0931-041X |
| Popis: | The impact of recombinant human growth hormone (rhGH) treatment on growth, bone mineral metabolism, and bone mineral density (BMD) was evaluated in six children (3 girls, 3 boys) with familial hypophosphatemic rickets (XLH). Five were prepubertal (aged 6–8.8 years), one 15.3-year-old boy had combined XLH and GH deficiency, but had not been treated with rhGH previously. rhGH was administered daily for 1 year, at a dose of 1 IU/kg per week, combined with 1,25-dihydroxyvitamin D3 and oral phosphate therapy. Z scores for growth velocity and height improved significantly (–2.9 vs. 2.5, P |
| Databáze: | OpenAIRE |
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