Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions
| Autor: | Vuong Cat Khanh, Hiromi Hamada, Motoo Osaka, Yun Hsuan Chang, Toshiharu Yamashita, Mana Obata-Yasuoka, Osamu Ohneda, Ngo Nhat Hoang, Mizuho Fukushige, Yuji Hiramatsu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Umbilical cord Umbilical Cord 0302 clinical medicine Original Research Reports Pregnancy Wharton's jelly DM Wharton Jelly Cells Cultured Hematology Cytokine release syndrome medicine.anatomical_structure cytokine storm Cytokines Female medicine.symptom Inflammation Mediators Cytokine Release Syndrome Adult Inflammation Biology Calu-3 cells Mesenchymal Stem Cell Transplantation Proinflammatory cytokine Diabetes Complications 03 medical and health sciences Extracellular Vesicles Downregulation and upregulation medicine Diabetes Mellitus Humans Aged Toxins Biological Uremia Dose-Response Relationship Drug SARS-CoV-2 Mesenchymal stem cell COVID-19 Mesenchymal Stem Cells Cell Biology medicine.disease Coculture Techniques 030104 developmental biology Glucose Gene Expression Regulation Immunology Cytokine storm 030217 neurology & neurosurgery RD Developmental Biology |
| Zdroj: | Stem Cells and Development |
| ISSN: | 1547-3287 |
| Popis: | Cytokine storm is recognized as one of the factors contributing to organ failures and mortality in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes mellitus (DM) or renal disease (RD) have more severe symptoms and higher mortality. However, the factors that contribute to severe outcomes of COVID-19 patients with DM and RD have received little attention. In an effort to investigate potential treatments for COVID-19, recent research has focused on the immunomodulation functions of mesenchymal stem cells (MSCs). In this study, the correlation between DM and RD and the severity of COVID-19 was examined by a combined approach with a meta-analysis and experimental research. The results of a systematic review and meta-analysis suggested that the odd of mortality in patients with both DM and RD was increased in comparison to those with a single comorbidity. In addition, in the experimental research, the data showed that high glucose and uremic toxins contributed to the induction of cytokine storm in human lung adenocarcinoma epithelial cells (Calu-3 cells) in response to SARS-CoV Peptide Pools. Of note, the incorporation of Wharton's jelly MSC-derived extracellular vesicles (WJ-EVs) into SARS-CoV peptide-induced Calu-3 resulted in a significant decrease in nuclear NF-κB p65 and the downregulation of the cytokine storm under high concentrations of glucose and uremic toxins. This clearly suggests the potential for WJ-EVs to reduce cytokine storm reactions in patients with both chronic inflammation diseases and viral infection. |
| Databáze: | OpenAIRE |
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