Trimetazidine as a potential neuroprotectant in transient global ischemia in gerbils: a behavioral and histological study
| Autor: | Susan J. Hemmings, Ashfaq Shuaib, Munawar Hussain, Shamus James, Sandra Wright, Saeeda Iqbal, Ali H. Rajput, Azaad Baziany |
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| Rok vydání: | 2002 |
| Předmět: |
Male
animal diseases medicine.medical_treatment Vasodilator Agents Intraperitoneal injection Ischemia Trimetazidine Morris water navigation task Motor Activity Gerbil Neuroprotection Hippocampus Drug Administration Schedule Prosencephalon parasitic diseases medicine Animals Molecular Biology Saline Stroke Neurons Cell Death business.industry General Neuroscience medicine.disease Disease Models Animal Neuroprotective Agents Treatment Outcome nervous system Ischemic Attack Transient Anesthesia sense organs Neurology (clinical) business Gerbillinae Developmental Biology medicine.drug |
| Zdroj: | Brain research. 928(1-2) |
| ISSN: | 0006-8993 |
| Popis: | The effect of Trimetazidine (TMZ) as a potential neuroprotectant against stroke was studied in the gerbil model of transient forebrain global ischemia. Animals were subjected to a 5-min period of ischemia and assessed 4 and 21 days later. Gerbils were divided into two groups: in group one, gerbils were treated with TMZ at a dose of 25 mg/kg given by intraperitoneal injection prior to ischemia. In group two, gerbils were treated with TMZ at a dose of 25 mg/kg given intraperitoneally after ischemia. Saline-injected gerbils served as controls. Histological evaluation of neuronal damage was carried out using the silver staining technique in gerbils 4 and 21 days after the start of the experimental protocol. Behavioral functions were assessed in gerbils from the 14th to the 21st day after the start of the experimental protocol using the Morris water maze test. Results obtained from this study showed no significant difference between saline treated TMZ-treated gerbils when TMZ was administered after ischemia. When TMZ was administered prior to ischemia, there was a reduction in neuronal damage although it did not reach statistical significance and a statistically significant improvement in behavior. We conclude that TMZ shows signs of promise as a neuroprotective agent, and further studies should look at pre-treatment with different doses and different times. |
| Databáze: | OpenAIRE |
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