Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

Autor:	Seyoum Ayehunie, Howard R. Mellor, Robert G. Vries, Alan Norris, Chris Probert, Alexander Penrose, Munir Pirmohamed, Shashi K. Ramaiah, B. Kevin Park, Alison Shaw, Andrea Davies, James E. Sidaway, Claire Sadler, Michael Schmitt, Syed A. Hussain, D. Mark Pritchard, Daniel F. Carr, Matthew Wagoner, Stephanie French, Carrie A. Duckworth, Neil Hall
Rok vydání:	2017
Předmět:	0301 basic medicine Drug medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Gastrointestinal Diseases media_common.quotation_subject Drug Evaluation Preclinical Gastrointestinal Injury Pharmacology Models Biological 03 medical and health sciences parasitic diseases Drug Discovery Toxicity Tests Medicine Animals Humans Pharmacology (medical) Drug reaction Intensive care medicine media_common Pharmaceutical industry business.industry social sciences medicine.disease 030104 developmental biology Drug Design population characteristics Biomarker (medicine) business human activities Healthcare providers geographic locations Adverse drug reaction Biomarkers
Zdroj:	PHARMACOLOGY & THERAPEUTICS
ISSN:	1879-016X
Popis:	Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/monitoring. We focus on the current gaps in our knowledge, the potential opportunities and recommend that a systematic approach is needed to identify mechanism-based GI biomarkers with potential for clinical translation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013fea942d2efe4f3854bdfe76704cec https://pubmed.ncbi.nlm.nih.gov/28132905 Zobrazit plný text záznamu Full Text from ScienceDirect