| Autor: |
Hongchun Li, Xuemei Wan, Zhixiang Wu, Yuanyi Zhou, Rong Chen, Wei Xu, Jiamei Zhang, Zhen Yang, Lin Bai, Jie Zhang, Feng Qin, Liang Wang, Yaxing Chen, Linhong Jiang, Yuman He, Xiaojie Wang, Qingfan Wei, Shu Li, Yanping Dai, Yuanyuan Chen, Yonghai Wang, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cell reports. 41(9) |
| ISSN: |
2211-1247 |
| Popis: |
Studies have shown the therapeutic effects of a ketogenic diet (KD) on epilepsy, but the effect of a KD on drug reinstatement is largely unclear. This study aims to investigate whether KD consumption possesses therapeutic potential for cocaine reinstatement and the molecular mechanism. We find that a KD significantly reduces cocaine-induced reinstatement in mice, which is accompanied by a markedly elevated level of β-hydroxybutyrate (β-OHB), the most abundant ketone body, in the hippocampus. The underlying mechanism is that β-OHB posttranslationally modifies CaMKII-α with β-hydroxybutyrylation, resulting in significant inhibition of T286 autophosphorylation and downregulation of CaMKII activity. Collectively, our results reveal that β-hydroxybutyrylation is a posttranslational modification of CaMKII-α that plays a critical role in mediating the effect of KD consumption in reducing cocaine reinstatement. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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