Diabetic cardiomyopathy: signaling defects and therapeutic approaches
| Autor: | Joseph S Dobrin, Djamel Lebeche |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Male Inotrope medicine.medical_specialty Risk Assessment Article Mitochondria Heart Diabetes Complications Coronary artery disease Insulin resistance Adipokines Diabetes mellitus Internal medicine Diabetic cardiomyopathy Internal Medicine medicine Humans Calcium Signaling Heart metabolism business.industry General Medicine Lipid Metabolism Prognosis medicine.disease Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Lipotoxicity Heart failure Cardiology Female Insulin Resistance Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | Expert Review of Cardiovascular Therapy. 8:373-391 |
| ISSN: | 1744-8344 1477-9072 |
| DOI: | 10.1586/erc.10.17 |
| Popis: | Diabetes mellitus is the world's fastest growing disease with high morbidity and mortality rates, predominantly as a result of heart failure. A significant number of diabetic patients exhibit diabetic cardiomyopathy; that is, left ventricular dysfunction independent of coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy is complex, and is characterized by dysregulated lipid metabolism, insulin resistance, mitochondrial dysfunction and disturbances in adipokine secretion and signaling. These abnormalities lead to impaired calcium homeostasis, ultimately resulting in lusitropic and inotropic defects. This article discusses the impact of these hallmark factors in diabetic cardiomyopathy, and concludes with a survey of available and emerging therapeutic modalities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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