Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761)
| Autor: | Alain Piriou, Kathy Drieu, François Huguet |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Aging medicine.medical_specialty Central nervous system Pharmaceutical Science Biology Pharmacology Binding Competitive Internal medicine medicine Animals Ginkgoales Rats Wistar Binding site Receptor Cerebral Cortex 8-Hydroxy-2-(di-n-propylamino)tetralin Binding Sites Plant Extracts Ginkgo biloba Cell Membrane biology.organism_classification Rats Endocrinology medicine.anatomical_structure Mechanism of action Ageing Cerebral cortex Receptors Serotonin medicine.symptom |
| Zdroj: | Journal of Pharmacy and Pharmacology. 46:316-318 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1994.tb03802.x |
| Popis: | Investigation of [3H]8-hydroxy-2(di-n-propylamino)tetralin binding to 5-HT1A receptors in cerebral cortex membranes of Wistar rats showed that the maximal number of binding sites (Bmax) was reduced significantly (22%) in aged (24-month-old) as compared with young (4-month-old) animals. Chronic treatment with Ginkgo biloba extract did not alter binding in young rats but increased binding density significantly (33%) in aged rats. These results confirm previously described age-related 5-hydroxytryptaminergic alterations. Together with data in the literature, they also suggest a restorative effect in aged rats, associated with decreased receptor density resulting from the protective action of Ginkgo biloba extract treatment on neuronal membrane. |
| Databáze: | OpenAIRE |
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