Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known
| Autor: | Christeva Montanede, John F. Kalaska, Chandramouli Chandrasekaran, Krishna V. Shenoy, Megan Wang, Diogo Peixoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Premotor cortex genetic structures Decision General Physics and Astronomy 02 engineering and technology Choice Behavior Macaque Task (project management) 0302 clinical medicine lcsh:Science media_common Neurons 0303 health sciences Multidisciplinary Behavior Animal biology Motor Cortex 021001 nanoscience & nanotechnology medicine.anatomical_structure Colored Checkerboard Cues 0210 nano-technology Psychology Dorsum Science media_common.quotation_subject Action selection behavioral disciplines and activities Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences biology.animal Perception Reaction Time medicine Animals Sensory cue 030304 developmental biology General Chemistry Macaca mulatta 030104 developmental biology lcsh:Q Neuroscience Photic Stimulation Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) Nature Communications |
| DOI: | 10.1101/412528 |
| Popis: | How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose colors alternated randomly between trials, by discriminating the dominant color of a checkerboard cue composed of different numbers of squares of the two target colors in different trials. In a Targets First task the colored targets appeared first, followed by the checkerboard; in a Checkerboard First task, this order was reversed. After both cues appeared in both tasks, responses of dorsal premotor cortex (PMd) units covaried with action choices, strength of evidence for action choices, and RTs— hallmarks of decision-related activity. However, very few units were modulated by checkerboard color composition or the color of the chosen target, even during the checkerboard deliberation epoch of the Checkerboard First task. These findings implicate PMd in the action-selection but not the perceptual components of the decision-making process in these tasks. It is not clear to what degree activity in dorsal premotor cortex (PMd) reflects perceptual-deliberation versus action-selection aspects of decision-making. Here, the authors report that monkey PMd neurons do not express correlates of the perceptual decision independently of the action choices. |
| Databáze: | OpenAIRE |
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