Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats

Autor: Anders Nordholm, Marya Morevati, Ewa Lewin, Søren Egstrand, Maria L. Mace, Klaus Olgaard, Eva Gravesen
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Physiology
Clinical Biochemistry
urologic and male genital diseases
Glucuronidase/blood
Phosphates/blood
0302 clinical medicine
Uremia/blood
Osteodystrophy
Activins/blood
Receptor
Klotho
Glucuronidase
Kidney
female genital diseases and pregnancy complications
Activins
Circadian Rhythm
medicine.anatomical_structure
Parathyroid Hormone
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
Phosphates
03 medical and health sciences
Rhythm
Physiology (medical)
Internal medicine
medicine
Animals
Circadian rhythm
Rats
Wistar
Renal Insufficiency
Chronic
Bone Diseases
Metabolic/blood
Klotho Proteins
Uremia
business.industry
Fibroblast Growth Factors/blood
medicine.disease
Molecular medicine
Rats
Fibroblast Growth Factors
Bone Diseases
Metabolic
030104 developmental biology
Endocrinology
Parathyroid Hormone/blood
Renal Insufficiency
Chronic/blood
business
030217 neurology & neurosurgery
Hormone
Zdroj: Nordholm, A, Egstrand, S, Gravesen, E, Mace, M L, Morevati, M, Ølgaard, K & Lewin, E 2019, ' Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats ', Pflügers Archiv-European Journal of Physiology, vol. 471, no. 8, pp. 1079-1094 . https://doi.org/10.1007/s00424-019-02291-2
ISSN: 1432-2013
DOI: 10.1007/s00424-019-02291-2
Popis: Activin A is a new fascinating player in chronic kidney disease-mineral and bone disorder (CKD-MBD), which is implicated in progressive renal disease, vascular calcification, and osteodystrophy. Plasma activin A rises early in the progression of renal disease. Disruption of circadian rhythms is related to increased risk of several diseases and circadian rhythms are observed in mineral homeostasis, bone parameters, and plasma levels of phosphate and PTH. Therefore, we examined the circadian rhythm of activin A and CKD-MBD-related parameters (phosphate, PTH, FGF23, and klotho) in healthy controls and CKD rats (5/6 nephrectomy) on high-, standard- and low-dietary phosphate contents as well as during fasting conditions. Plasma activin A exhibited circadian rhythmicity in healthy control rats with fourfold higher values at acrophase compared with nadir. The rhythm was obliterated in CKD. Activin A was higher in CKD rats compared with controls when measured at daytime but not significantly when measured at evening/nighttime, stressing the importance of time-specific reference intervals when interpreting plasma values. Plasma phosphate, PTH, and FGF23 all showed circadian rhythms in control rats, which were abolished or disrupted in CKD. Plasma klotho did not show circadian rhythm. Thus, the present investigation shows, for the first time, circadian rhythm of plasma activin A. The rhythmicity is severely disturbed by CKD and is associated with disturbed rhythms of phosphate and phosphate-regulating hormones PTH and FGF23, indicating that disturbed circadian rhythmicity is an important feature of CKD-MBD.
Databáze: OpenAIRE
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