Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma
| Autor: | Yujing Zhang, Jian-Xin Wan, Li-Na Lin, Jian-Rong Mai, Zhong-Ning Lin, Yan-fang Gao, H. Chen, Chen-Zi Zhang, Bin Xia, Song-Zi Wang, Yuxi Chen, Kun Liao, Yu-Chun Lin |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Carcinoma Hepatocellular Transcription Genetic Epidemiology lcsh:Medicine Biology Polymorphism Single Nucleotide medicine Biomarkers Tumor Genetics Humans Genetic Predisposition to Disease Protein Phosphatase 2 lcsh:Science Promoter Regions Genetic Multidisciplinary Population Biology lcsh:R Liver Neoplasms NF-kappa B DNA Methylation medicine.disease Gene Expression Regulation Neoplastic Haplotypes Hepatocellular carcinoma Genetic Polymorphism Medicine lcsh:Q Female Epigenetics DNA modification Population Genetics Cancer Epidemiology Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 3, p e59574 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Previously, we identified the genetic variant -241 (-/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may be regulated by NF-κB through the functional genetic variant -241 (-/G). Moreover, we also demonstrated that the methylation status of CpG islands in the promoter of PPP2R1A influences the activity of this gene promoter. Few studies have examined the role of this -241 (-/G) variant in genetic or epigenetic regulation in hepatocellular carcinoma (HCC). To investigate whether this functional variant in the PPP2R1A promoter is associated with the risk of HCC and confirm the function of the -241 (-/G) variant in the HCC population, we conducted a case-control study involving 251 HCC cases and 252 cancer-free controls from a Han population in southern China. Compared with the -241 (--) homozygote, the heterozygous -241 (-G) genotype (adjusted OR = 0.32, 95% confidence interval (CI) = 0.17-0.58, P |
| Databáze: | OpenAIRE |
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