Heme Oxygenase-1 and Autophagy Linked for Cytoprotection
| Autor: | Leonardo H. Travassos, Mariana S. Siqueira, Luiz Ricardo Vasconcellos, Leticia A.M. Carneiro, R Moraes, Marcelo T. Bozza |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Chemistry Autophagy Inflammation medicine.disease_cause Cytoprotection Homeostatic Process Gene Expression Regulation Enzymologic Cell biology Heme oxygenase 03 medical and health sciences Cytosol 030104 developmental biology Stress Physiological Drug Discovery medicine Animals Homeostasis Humans medicine.symptom Oxidative stress Heme Oxygenase-1 |
| Zdroj: | Current pharmaceutical design. 24(20) |
| ISSN: | 1873-4286 |
| Popis: | Background: Heme-oxygenase (HO) catalyzes the main enzymatic step of heme degradation and generates anti-inflammatory end products with protective roles in physiological and pathological situations. The importance of HO in pathological conditions is evidenced by its pharmacological inhibition or genetic blockage in different models of stress such as infection, inflammation and oxidative stress. Under these situations, another well-known protective process triggered is autophagy. Autophagy is a homeostatic process that eliminates defective cytosolic components and organelles, allowing cells and tissues to recover through recycling of functional blocks for anabolic reactions. Recently, studies have demonstrated a link between HO activity and autophagy activation. Objective: In this review, we focus on the interplay between HO and autophagy, and highlight its importance in homeostasis maintenance under stress conditions. |
| Databáze: | OpenAIRE |
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