Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus
| Autor: | Ahmet Carhan, Nilay Yuksel, Berrak Gumuskaya Ocal, Berna Ayan, Emine Akcay, Mehmet Asik, Nurullah Cagil |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Keratoconus Adolescent genetic structures medicine.drug_class Real-Time Polymerase Chain Reaction Andrology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Prospective Studies RNA Messenger Receptor Progesterone Corneal epithelium business.industry Epithelium Corneal Estrogens General Medicine medicine.disease Androgen Immunohistochemistry eye diseases Androgen receptor Ophthalmology medicine.anatomical_structure Receptors Androgen Estrogen Sex steroid Hormone receptor 030221 ophthalmology & optometry Female sense organs business 030217 neurology & neurosurgery Optometry |
| Zdroj: | Contact Lens and Anterior Eye. 42:492-496 |
| ISSN: | 1367-0484 |
| Popis: | Purpose To evaluate the role of sex steroid hormone receptors in corneal epithelium in etiopathogenesis of keratoconus (KC). Methods Thirty patients with KC who were planned for corneal collagen-crosslinking and 20 patients who were planned for excimer laser for refractive errors included in this study. Corneal epitheliums were curated mechanically during surgeries. Right eyes were evaluated immunohistochemically and left eyes were evaluated by quantitative polymerase chain reaction (qPCR) to investigate estrogenα, estrogenβ, progesterone and androgen receptors. Results Immunohistochemically, staining for progesterone and androgen receptors did not significantly differ between KC and control groups (p > 0.05). None of the cases had staining for estrogenα and estrogenβ receptors. qPCR showed that mRNA expressions of estrogenα and androgen receptors were significantly higher in the KC group (p Conclusion A significantly higher rate of estrogenα and androgen receptor expressions in corneal epithelium from patients with KC through qPCR supports a possible relation between KC and sex steroid hormones. |
| Databáze: | OpenAIRE |
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