Diabetes Care, Glycemic Control, Complications, and Concomitant Autoimmune Diseases in Children with Type 1 Diabetes in Turkey: A Multicenter Study

Autor: Ilknur Arslanoglu, Zehra Aycan, Korcan Demir, Şükran Darcan, Ayça Altıncık, Murat Aydin, Gülgün Asar, Damla Gökşen Şimşek, Samim Özen, Zerrin Orbak, Cengiz Kara, Serap Semiz, Ozgul Tunc, Gönül Öcal, Behzat Özkan, Ayşenur Ökten, Rüveyde Bundak, Ergun Cetinkaya, Zeynep Şıklar, Ahmet Uçaktürk, Saygin Abali, Semra Çetinkaya, Firdevs Bas, Olcay Evliyaoğlu, Gülay Karagüzel
Přispěvatelé: Ege Üniversitesi, Kırıkkale Üniversitesi, OMÜ
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Blood Glucose
Male
electromyography
obesity
endocrine system diseases
Turkey
Endocrinology
Diabetes and Metabolism
thyroid peroxidase
preschool child
low density lipoprotein cholesterol
thyrotropin
Endocrinology
high density lipoprotein cholesterol
ketoacidosis
newborn
Insulin
Child
hemoglobin A1c
Hashimoto disease
adult
creatinine
thyrotropin receptor antibody
article
blood pressure
continuous infusion
female
Type 1 diabetes
insulin pump
Child
Preschool
Graves disease
Original Article
Insulin pump
medicine.medical_specialty
microalbuminuria
Adolescent
complications
autoimmune disease
Hypoglycemia
insulin dependent diabetes mellitus
Autoimmune Diseases
Young Adult
children
Internal medicine
Diabetes mellitus
retinopathy
medicine
cross-sectional study
follow up
Humans
human
ophthalmoscopy
albumin
Glycemic
thyroxine
Glycated Hemoglobin
Hemoglobin A
Glycosylated
business.industry
dyslipidemia
nutritional and metabolic diseases
cholesterol
scoring system
Infant
medicine.disease
school child
protein glutamine gamma glutamyltransferase antibody
major clinical study
Surgery
Ketoacidosis
short stature
hypoglycemia
Cross-Sectional Studies
Diabetes Mellitus
Type 1
thyroglobulin antibody
Pediatrics
Perinatology and Child Health
glycemic control
Microalbuminuria
neuropathy
hyperglycemia
metabolic regulation
business
Dyslipidemia
celiac disease
Zdroj: Journal of Clinical Research in Pediatric Endocrinology
Popis: WOS: 000339649100004
PubMed ID: 23419424
Objective: Epidemiologic and clinical features of type 1 diabetes mellitus (T1DM) may show substantial differences among countries. The primary goal in the management of T1DM is to prevent micro- and macrovascular complications by achieving good glycemic control. The present study aimed to assess metabolic control, presence of concomitant autoimmune diseases, and of acute and long-term complications in patients diagnosed with T1DM during childhood and adolescence. The study also aimed to be a first step in the development of a national registry system for T1DM, in Turkey. Methods: Based on hospital records, this cross-sectional, multicenter study included 1 032 patients with T1DM from 12 different centers in Turkey, in whom the diagnosis was established during childhood. Epidemiological and clinical characteristics of the patients were recorded. Metabolic control, diabetes care, complications, and concomitant autoimmune diseases were evaluated. Results: Mean age, diabetes duration, and hemoglobin A1c level were 12.5 +/- 4.1 years, 4.7 +/- 3.2 years, and 8.5 +/- 1.6%, respectively. Acute complications noted in the past year included ketoacidosis in 5.2% of the patients and severe hypoglycemia in 4.9%. Chronic lymphocytic thyroiditis was noted in 12%, Graves' disease in 0.1%, and celiac disease in 4.3% of the patients. Chronic complications including neuropathy, retinopathy, and persistent microalbuminuria were present in 2.6%, 1.4%, and 5.4% of the patients, respectively. Diabetic nephropathy was not present in any of the patients. Mean diabetes duration and age of patients with neuropathy, retinopathy and microalbuminuria were significantly different from the patients without these long-term complications (p
Databáze: OpenAIRE
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