Diabetes Care, Glycemic Control, Complications, and Concomitant Autoimmune Diseases in Children with Type 1 Diabetes in Turkey: A Multicenter Study
Autor: | Ilknur Arslanoglu, Zehra Aycan, Korcan Demir, Şükran Darcan, Ayça Altıncık, Murat Aydin, Gülgün Asar, Damla Gökşen Şimşek, Samim Özen, Zerrin Orbak, Cengiz Kara, Serap Semiz, Ozgul Tunc, Gönül Öcal, Behzat Özkan, Ayşenur Ökten, Rüveyde Bundak, Ergun Cetinkaya, Zeynep Şıklar, Ahmet Uçaktürk, Saygin Abali, Semra Çetinkaya, Firdevs Bas, Olcay Evliyaoğlu, Gülay Karagüzel |
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Přispěvatelé: | Ege Üniversitesi, Kırıkkale Üniversitesi, OMÜ |
Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Blood Glucose
Male electromyography obesity endocrine system diseases Turkey Endocrinology Diabetes and Metabolism thyroid peroxidase preschool child low density lipoprotein cholesterol thyrotropin Endocrinology high density lipoprotein cholesterol ketoacidosis newborn Insulin Child hemoglobin A1c Hashimoto disease adult creatinine thyrotropin receptor antibody article blood pressure continuous infusion female Type 1 diabetes insulin pump Child Preschool Graves disease Original Article Insulin pump medicine.medical_specialty microalbuminuria Adolescent complications autoimmune disease Hypoglycemia insulin dependent diabetes mellitus Autoimmune Diseases Young Adult children Internal medicine Diabetes mellitus retinopathy medicine cross-sectional study follow up Humans human ophthalmoscopy albumin Glycemic thyroxine Glycated Hemoglobin Hemoglobin A Glycosylated business.industry dyslipidemia nutritional and metabolic diseases cholesterol scoring system Infant medicine.disease school child protein glutamine gamma glutamyltransferase antibody major clinical study Surgery Ketoacidosis short stature hypoglycemia Cross-Sectional Studies Diabetes Mellitus Type 1 thyroglobulin antibody Pediatrics Perinatology and Child Health glycemic control Microalbuminuria neuropathy hyperglycemia metabolic regulation business Dyslipidemia celiac disease |
Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
Popis: | WOS: 000339649100004 PubMed ID: 23419424 Objective: Epidemiologic and clinical features of type 1 diabetes mellitus (T1DM) may show substantial differences among countries. The primary goal in the management of T1DM is to prevent micro- and macrovascular complications by achieving good glycemic control. The present study aimed to assess metabolic control, presence of concomitant autoimmune diseases, and of acute and long-term complications in patients diagnosed with T1DM during childhood and adolescence. The study also aimed to be a first step in the development of a national registry system for T1DM, in Turkey. Methods: Based on hospital records, this cross-sectional, multicenter study included 1 032 patients with T1DM from 12 different centers in Turkey, in whom the diagnosis was established during childhood. Epidemiological and clinical characteristics of the patients were recorded. Metabolic control, diabetes care, complications, and concomitant autoimmune diseases were evaluated. Results: Mean age, diabetes duration, and hemoglobin A1c level were 12.5 +/- 4.1 years, 4.7 +/- 3.2 years, and 8.5 +/- 1.6%, respectively. Acute complications noted in the past year included ketoacidosis in 5.2% of the patients and severe hypoglycemia in 4.9%. Chronic lymphocytic thyroiditis was noted in 12%, Graves' disease in 0.1%, and celiac disease in 4.3% of the patients. Chronic complications including neuropathy, retinopathy, and persistent microalbuminuria were present in 2.6%, 1.4%, and 5.4% of the patients, respectively. Diabetic nephropathy was not present in any of the patients. Mean diabetes duration and age of patients with neuropathy, retinopathy and microalbuminuria were significantly different from the patients without these long-term complications (p |
Databáze: | OpenAIRE |
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