Tumour Response 3 Months after Neoadjuvant Single-Fraction Radiotherapy for Low-Risk Breast Cancer
| Autor: | Mai-Kim Gervais, Lucas Sideris, Duc X. Nguyen, Tarek Hijal, Michael A. Yassa, D. Tiberi, Pierre Dubé, M P Dufresne, A. Simon-Cloutier, Guy Leblanc, M.C. Guilbert, P. Vavassis |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Time Factors preoperative radiotherapy Short Communication medicine.medical_treatment Breast Neoplasms Tumour response New diagnosis Radiosurgery 03 medical and health sciences Breast cancer 0302 clinical medicine Internal medicine medicine Clinical endpoint Humans 030212 general & internal medicine skin and connective tissue diseases sbrt Aged sabr Aged 80 and over business.industry Standard treatment radiosurgery medicine.disease Single fraction Radiation therapy ablative radiotherapy 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant business |
| Zdroj: | Curr Oncol Current Oncology Volume 27 Issue 3 Pages 6059-158 |
| ISSN: | 1718-7729 |
| DOI: | 10.3747/co.27.6059 |
| Popis: | Standard treatment for early-stage invasive breast cancer (bca) consists of breast-conserving surgery and several weeks of adjuvant radiotherapy (rt). Neoadjuvant single-fraction rt is a novel approach for early-stage bca. We sought to investigate the effect of delaying surgery after neoadjuvant rt with respect to the rate of pathologic response (pr). Women 65 years of age or older with a new diagnosis of stage i luminal A bca were eligible for inclusion. A single 20 Gy dose to the primary breast tumour was given, followed by breast-conserving surgery 3 months later. The primary endpoint was the pr rate assessed by microscopic evaluation using the Miller&ndash Payne system. To date, 10 patients have been successfully treated. Median age of the patients was 72 years (range: 65&ndash 84 years). In 8 patients, neoadjuvant rt resulted in a tumour pr with median residual cellularity of 3%. No immediate rt complications other than mild dermatitis were noted. This study demonstrates a method for delivering single-fraction rt that can lead to a high level of pr in most patients. Continued accrual to this study and subsequent trials are needed to determine the feasibility, safety, and role of this novel technique in the management of early-stage bca. |
| Databáze: | OpenAIRE |
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