The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide
| Autor: | Özden Kutlay, Esra Aslan, Arzu Keskin-Aktan |
|---|---|
| Přispěvatelé: | Kutlay, Özden, Keskin Aktan, Arzu, Aslan, Esra |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Cyclophosphamide Physiology medicine.medical_treatment Cyclophosphamide toxicity Endogeny Pharmacology Antioxidants Physiology (medical) Medicine Animals Apelin-13 Rats Wistar Nephrotoxicity Apeline-13 Néphrotoxicité Toxicité de la cyclophosphamide business.industry General Medicine Cardiotoxicity Apelin Rats Oxidative Stress Toxicity Intercellular Signaling Peptides and Proteins Chemotherapeutic drugs business Cardiotoxicité medicine.drug |
| Zdroj: | Canadian journal of physiology and pharmacology. 100(4) |
| ISSN: | 1205-7541 |
| Popis: | Cyclophosphamide is a chemotherapeutic drug that is widely used in the clinic and can cause multi-organ toxicity. Apelin-13 is an endogenous adipocytokine with antioxidant properties. Therefore, this study investigated the possibility of apelin-13 being a potential therapeutic agent on cardiac toxicity and nephrotoxicity caused by cyclophosphamide. In this study, a total of four groups were formed with eight rats in each group. Group I: the control group was administered only saline (i.p.). Group II: cyclophosphamide, a single dose of 200 mg/kg (i.p.) on day 7. Group III: apelin-13 (15 μg/kg), for 7 days (i.p.). Group IV: administered apelin-13 (15 μg/kg) (i.p.) for 7 days and a single dose of cyclophosphamide (200 mg/kg) (i.p.) on day 7, the rats were sacrificed on day 8. Lactate dehydrogenase, cardiac troponin I (cTnI), creatine kinase MB (CK-MB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), malondialdehyde, creatinine, and blood urea nitrogen were found to be high in the cyclophosphamide group; however, these values were reduced with apelin-13 administration. Antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, and reduced glutathione (GSH) decreased in the cyclophosphamide group, and apelin-13 increased these enzyme activities. In addition, histopathological examinations also supported the results obtained. The findings of this study showed that apelin-13 has a protective effect against cardiorenal toxicity caused by cyclophosphamide. |
| Databáze: | OpenAIRE |
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