Cystic fibrosis, gastroduodenal inflammation, duodenal ulcer, and H. pylori infection: The 'cystic fibrosis paradox' revisited
| Autor: | Rhaissa Said Carvalho, Luciana Dias Moretzsohn, Luiz Gonzaga Vaz Coelho, Maria do Carmo Friche Passos, Marcelo Bicalho de Fuccio, Alfredo José Afonso Barbosa, Ana Flávia Passos Ramos |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Adolescent Cystic Fibrosis Inflammation Cystic fibrosis Gastroenterology Endoscopy Gastrointestinal Helicobacter Infections Young Adult Internal medicine Prevalence medicine Humans Pediatrics Perinatology and Child Health Young adult Aged Breath test Duodenitis Helicobacter pylori medicine.diagnostic_test biology business.industry Histology Middle Aged medicine.disease biology.organism_classification digestive system diseases Endoscopy Duodenal Ulcer Gastritis Pediatrics Perinatology and Child Health Gastric acid Female medicine.symptom business |
| Zdroj: | Journal of Cystic Fibrosis. 12:377-383 |
| ISSN: | 1569-1993 |
| Popis: | Background In cystic fibrosis (CF) patients a duodenal impaired bicarbonate secretion and unbuffered gastric acid are always described and the development of duodenal ulceration is uncommon (CF paradox). Helicobacter pylori (HP) infection is the main cause for duodenal ulceration and its prevalence in CF patients is controversial. Aim The objective of this study is to evaluate HP prevalence, gastric histology, and duodenal ulceration in adult FC patients. Methods 32 adult CF patients were submitted to 13 C-urea breath test and serum immunoblotting test for HP diagnosis. Among them, 20 patients were submitted to endoscopy. Results 19/32 (68%) patients showed positive serology. Endoscopy showed erosive duodenitis (15%), and duodenal ulcer scar in 10%. On duodenal histology, 94.5%, showed active inflammation and 66.7% gastric metaplasia. Conclusion HP infection prevalence in adult CF patients was similar to that of general Brazilian population. CF patients have all the duodenal spectrum of alterations, including duodenal ulcer. CF paradox may not exist. |
| Databáze: | OpenAIRE |
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