Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
| Autor: | Omar Galdame, Leonardo Fainboim, Natalia Paladino, Alberto Muñoz, Teresa Schroder, Ana C. Flores, G. Theiler, Hugo Fainboim |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cirrhosis Hepatitis C virus Immunology Biology medicine.disease_cause Lower risk Microbiology Virus Sex Factors Virology Genotype medicine Humans Genetic Predisposition to Disease Polymorphism Promoter Regions Genetic Aged Polymorphism Genetic Hepatitis C purl.org/becyt/ford/3.1 [https] Middle Aged medicine.disease Fibrosis Interleukin-10 Genotype frequency Liver Insect Science Pathogenesis and Immunity Female purl.org/becyt/ford/3 [https] Viral disease |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| DOI: | 10.1128/JVI.00339-06 |
| Popis: | Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA+). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA+ female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA - patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA- patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA+ patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved. Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fainboim, Hugo. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina Fil: Theiler, Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Schroder, Teresa. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina Fil: Muñoz, Alberto Eduardo. Hospital de Gastroenterología Dr. C. Bonorino Udaondo. Unidad de Hepatología; Argentina Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Galdame, Omar. Hospital Italiano; Argentina Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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