Genome-wide analysis of primary peripheral blood mononuclear cells from HIV + patients-pre-and post- HAART show immune activation and inflammation the main drivers of host gene expression

Autor:	Nitin K. Saksena, Kaushal S. Gandhi, Wayne B. Dyer, Priyanka Gupta, Viviane Conceicao
Rok vydání:	2014
Předmět:	Microarray analysis techniques Genetic enhancement virus diseases Inflammation Viremia Biology medicine.disease Peripheral blood mononuclear cell Virology Immune system Gene expression Immunology medicine medicine.symptom Gene Research Article
Zdroj:	Molecular and cellular therapies
ISSN:	2052-8426
Popis:	Background Although the host gene expression in the context of HIV has been explored by several studies, it remains unclear how HIV is able to manipulate and subvert host gene machinery before and after highly active antiretroviral therapy (HAART) in the same individual. In order to define the underlying pharmaco-genomic basis of HIV control during HAART and genomic basis of immune deterioration prior to HAART initiation, we performed a genome-wide expression analysis using primary peripheral blood mononuclear cells (PBMC) derived from 14 HIV + subjects pre-highly active antiretroviral therapy (HAART) (time point-1 or TP1) with detectable plasma viremia and post-HAART (time point-2 or TP2) with effective control of plasma viremia (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012f77b0bafaa7897639e4839f1a004a https://doi.org/10.1186/2052-8426-2-11 Zobrazit plný text záznamu Full text from SpringerLink