A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
| Autor: | Mark J. Sterling, Lori Olans, Michael B. Russell, Monika Pilichowska, Sara Zelman, Amin Hojat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal tract Pathology biology Colon business.industry Rectosigmoid Colon Waldenstrom macroglobulinemia Case Report General Medicine medicine.disease Lymphoma medicine.anatomical_structure Immunoglobulin M medicine biology.protein Immunohistochemistry Histopathology Bone marrow business |
| Zdroj: | ACG Case Reports Journal |
| ISSN: | 2326-3253 |
| DOI: | 10.14309/crj.0000000000000689 |
| Popis: | Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens. |
| Databáze: | OpenAIRE |
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