Exhaled Nitric Oxide Measurements in a Population Sample of Young Adults
| Autor: | Alyson M. Roberts, Guy B. Marks, Nathan J. Brown, Cheryl M. Salome, John Dermand, Ann J. Woolcock |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.drug_class Intraclass correlation Nitric Oxide Critical Care and Intensive Care Medicine Gastroenterology Bronchial Provocation Tests chemistry.chemical_compound Forced Expiratory Volume Internal medicine Wheeze Bronchodilator medicine Humans Child Respiratory Sounds Asthma Dose-Response Relationship Drug business.industry Reproducibility of Results respiratory system medicine.disease Confidence interval respiratory tract diseases Breath Tests chemistry Anesthesia Exhaled nitric oxide Bronchial Hyperreactivity medicine.symptom Airway business Histamine Follow-Up Studies |
| Zdroj: | ResearcherID |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.159.3.9802108 |
| Popis: | In epidemiologic studies of asthma there is a group with recent wheeze, but with no airway hyperresponsiveness (AHR), in whom it is unclear whether any significant airway abnormality exists. Exhaled nitric oxide (NO) has been proposed as a measure of airway inflammation. We measured exhaled NO in a population sample of 306 young adults who also underwent bronchial challenge with histamine or a bronchodilator test. Subjects blew into a 3-L Tedlar bag against a 2-mm-diameter resistance to close the soft palate and exclude nasal air. The NO content of expired gas from a single breath was analyzed by chemiluminescent analyzer. Exhaled NO was log-normally distributed in the population sample and duplicate measurements were highly reproducible (intraclass correlation coefficient = 0.98). Exhaled NO correlated significantly with airway responsiveness, measured as the dose-response ratio to histamine (r = 0.39, p < 0.001) and with peripheral blood eosinophils (r = 0.35, p < 0.001). Exhaled NO was significantly greater in asthmatic subjects (geometric mean, 22.2; 95% confidence intervals, 16.1 to 30.7 ppb) than in normal subjects (7.8, 7.1 to 8.4, p < 0.001) or in subjects with wheeze but no AHR (8.8, 7.5 to 10.3, p < 0.001). We conclude that exhaled NO is log-normally distributed, is highly reproducible and discriminates well among subjects, suggesting that it is both a feasible and useful measurement for epidemiologic studies of asthma. The findings suggest that wheeze in the absence of AHR is unlikely to be associated with airway inflammation. |
| Databáze: | OpenAIRE |
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