The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms
| Autor: | Melanie S. Flint, Marta Falcinelli, Susan K. Lutgendorf, Suzanne D. Conzen, Premal H. Thaker, Renée L. Flaherty |
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| Rok vydání: | 2021 |
| Předmět: |
Risk
Cancer Research Psychologic stress DNA Repair Carcinogenesis Disease Bioinformatics medicine.disease_cause Article Epigenesis Genetic Fight-or-flight response Risk Factors Neoplasms Humans Medicine Malignant cells Psychological stress Clinical significance Germ-Line Mutation Inflammation business.industry Stressor Cancer Middle Aged medicine.disease Hormones Cell Transformation Neoplastic Oncology Disease Progression Female business Stress Psychological DNA Damage Psychophysiology |
| Zdroj: | Cancer Res |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-21-0684 |
| Popis: | The hypothesis that the physiologic response to psychologic stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychologic stress response, and disease is plausible, considering that the stress response is associated with defined physiologic outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychologic stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation. |
| Databáze: | OpenAIRE |
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