Association of T CD4 Lymphocyte Levels and Chronic Periodontitis in HIV-Infected Brazilian Patients Undergoing Highly Active Anti-Retroviral Therapy: Clinical Results
| Autor: | Lúcia Helena Costinha, German Eduardo Miguel Villoria, Lucio Souza Gonçalves, Ana Paula Vieira Colombo, Sonia Maria Soares Ferreira, Arley Silva |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male medicine.medical_specialty medicine.medical_treatment Bleeding on probing HIV Infections Gastroenterology Antiretroviral Therapy Highly Active Internal medicine Hiv infected Periodontal Attachment Loss Epidemiology medicine Humans Periodontal Pocket Periodontitis business.industry Medical record Highly active anti-retroviral therapy Immunosuppression medicine.disease Chronic periodontitis CD4 Lymphocyte Count Chronic Disease Immunology Periodontics Female CD4 Lymphocyte Periodontal Index medicine.symptom Epidemiologic Methods business |
| Zdroj: | Journal of Periodontology. 76:915-922 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.2005.76.6.915 |
| Popis: | Controversial data regarding the association between immunosuppression and prevalence/ severity of periodontal diseases in HIV infection have been reported. Thus, the aim of this study was to test the hypothesis that lower T CD4 lymphocyte levels are not related to a higher prevalence of chronic periodontitis in HIV-infected Brazilians undergoing highly active anti-retroviral therapy (HAART).Sixty-four HIV-infected patients under HAART were classified as having chronic periodontitis; i.e.,or = three sites with probing depth (PD) and/or clinical attachment level (CAL)or = 5 mm or periodontal healthy (no sites with PD3 mm and/or CAL4 mm). All subjects received conventional periodontal therapy. Bleeding on probing, plaque accumulation, PD, and CAL were registered at six sites/tooth at baseline and 4 months after therapy. Epidemiological features and levels of T CD4 lymphocytes were obtained from medical records. Significance of differences in periodontal clinical parameters within and between groups were determined using Wilcoxon signed-rank and Mann-Whitney or independent sample t tests. Associations between T CD4 levels and clinical parameters were determined using the chi square test.Sixty-one percent of the HIV-infected patients represented AIDS cases, although 69% of them were periodontally healthy. The overall T CD4 lymphocyte mean levels was 333 +/- 254 cells/mm3 and viral load was 12,815 +/- 24,607 copies/mm3. Yet the prevalence of chronic periodontitis was relatively low (36%). In addition, patients with periodontitis presented a moderate disease (mean PD = 2.2 +/- 0.10; mean CAL = 2.6 +/- 0.13) and responded successfully to periodontal therapy. These subjects showed higher levels of T CD4 cells, but lower counts of neutrophils than periodontally healthy patients. Among periodontally healthy and chronic periodontitis patients, 41.7% and 22.9%, respectively, had low levels of T CD4 lymphocytes. No significant differences between periodontal status and epidemiological and immunological parameters were observed.Based on these results, the hypothesis that lower T CD4 lymphocyte levels are not associated with higher prevalence of chronic periodontitis in HIV-infected Brazilians under HAART cannot be rejected. |
| Databáze: | OpenAIRE |
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