Serum PAPP-A and free beta-hCG are first-trimester screening markers for Down syndrome
Autor: | Bruno Brambati, Y. Suzuki, J. G. Grudzinskas, Lucia Tului, I. Bonacchi, K. Shrimanker |
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Rok vydání: | 1994 |
Předmět: |
Adult
medicine.medical_specialty Pregnancy-associated plasma protein A Radioimmunoassay Chorionic villus sampling Gestational Age Biology Chorionic Gonadotropin Pregnancy Internal medicine medicine Humans Pregnancy-Associated Plasma Protein-A Chorionic Gonadotropin beta Subunit Human Genetics (clinical) Retrospective Studies Gynecology medicine.diagnostic_test Obstetrics and Gynecology Gestational age medicine.disease Aneuploidy Blood proteins Confidence interval Peptide Fragments Endocrinology Chorionic Villi Sampling ROC Curve Gestation Female Down Syndrome Trisomy Biomarkers Maternal Age |
Zdroj: | Prenatal diagnosis. 14(11) |
ISSN: | 0197-3851 |
Popis: | Serum measurements of pregnancy-associated plasma protein A (PAPP-A) and the free beta-human chorionic gonadotrophin (hCG) subunit were made in 13 women with Down syndrome (DS) pregnancies and six other women with fetal aneuploidy ascertained at chorionic villus sampling (CVS), as well as 89 women with contemporaneous normal control pregnancies. Median serum PAPP-A measurements (0.31 MOM, 95 per cent confidence interval (CI) 0.22-0.65 vs. normal 1.06, 95 per cent CI 0.89-1.20) were lower and free beta-hCG subunit measurements (1.13 MOM, 95 per cent CI 0.93-2.63 vs. normal 0.91, 95 per cent CI 0.79-1.03) were higher at statistically significant levels. Receiver operator characteristics (ROC) curves showed that the highest sensitivity for detection, 71.2 per cent (95 per cent CI 54.7-87.6 per cent), was for depressed PAPP-A levels; the combination of low serum PAPP-A levels, maternal age, and elevated free beta-hCG levels yielded a detection rate of 78.9 per cent (95 per cent CI 64.9-92.8 per cent) of the affected pregnancies at 8-12 weeks' gestation. |
Databáze: | OpenAIRE |
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