Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid‐core‐peptides
| Autor: | Sarah Hook, Karen L. White, Istvan Toth, Philip Kearns |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cytotoxicity
Immunologic Ovalbumin Lipoproteins medicine.medical_treatment Immunology Antigen-Presenting Cells Epitopes T-Lymphocyte Mice Inbred Strains Peptide CD8-Positive T-Lymphocytes Biology Cancer Vaccines Epitope Mice Immune system Adjuvants Immunologic Antigen Immunity medicine Animals Immunology and Allergy Cytotoxic T cell Polylysine chemistry.chemical_classification Histocompatibility Antigens Class I Neoplasms Experimental Cell Biology Molecular biology Peptide Fragments In vitro Cell biology chemistry Adjuvant |
| Zdroj: | Immunology & Cell Biology. 82:517-522 |
| ISSN: | 1440-1711 0818-9641 |
| DOI: | 10.1111/j.0818-9641.2004.01269.x |
| Popis: | A problem facing the use of subunit peptide and protein vaccines is their inability to stimulate protective immune responses. Many different approaches have been utilized to overcome this inefficient immune activation. The approach we have taken is to modify the vaccine antigen so that it now has adjuvant properties. To do this, multiple copies of minimal CD8 T cell epitopes were attached to a poly lysine lipid core. These constructs are known as lipid-core-peptides (LCP). The research presented here examines the adjuvant activity of LCP. Using mouse models, we were able to show that LCP were indeed able to activate antigen-presenting cells in vitro and to activate cytotoxic T-cell responses in vivo. More importantly, LCP were able to stimulate the development of a protective antitumour immune response. |
| Databáze: | OpenAIRE |
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