Electronic dura mater for long-term multimodal neural interfaces
| Autor: | Pavel Musienko, Simone Duis, Grégoire Courtine, Nikolaus Wenger, Rafael Fajardo Torres, Stéphanie P. Lacour, Qihan Liu, Silvestro Micera, Tomislav Milekovic, Alexandre Larmagnac, Ivan R. Minev, Jerome Gandar, Marco Capogrosso, Zhigang Suo, Leonie Asboth, Arthur Hirsch, Janos Vörös, Nicolas Vachicouras, Quentin Barraud, Eduardo Martin Moraud, N. V. Pavlova |
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| Rok vydání: | 2015 |
| Předmět: |
Silicon
Materials science Electrochemotherapy Dura mater Inbred Strains Biocompatible Materials Neural tissues Multimodal Imaging Mice Drug Delivery Systems medicine Animals Brain-Computer Interfaces Elasticity Electric Stimulation Locomotion Mice Inbred Strains Motor Cortex Neurons Paralysis Platinum Spinal Cord Spinal Cord Injuries Dura Mater Electrodes Implanted Prostheses and Implants Multidisciplinary Medicine (all) Electrodes Spinal cord injury Brain–computer interface Multimodal imaging medicine.disease Spinal cord Neuromodulation (medicine) Brain implant medicine.anatomical_structure Implanted Biomedical engineering |
| Zdroj: | Science. 347:159-163 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Mechanically soft neural implants When implanting a material into the body, not only does it need the right functional properties, but it also needs to have mechanical properties that match the native tissue or organ. If the material is too soft, it will be mechanically degraded, and if it is too hard it may get covered with scar tissue or it may damage the surrounding tissues. Starting with a transparent silicone substrate, Minev et al. patterned microfluidic channels to allow for drug delivery, and soft platinum/silicone electrodes and stretchable gold interconnects for transmitting electrical excitations and transferring electrophysiological signals. In tests of spinal cord implants, the soft neural implants showed biointegration and functionality within the central nervous system. Science , this issue p. 159 |
| Databáze: | OpenAIRE |
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