Influence of the Serotonergic System Polymorphism on the Expression of Dental Anxiety

Autor: Željko Verzak, Tanja Franceski, Dalibor Karlović, Rudolf Ljubičić, Ante Silić, Vjekoslav Peitl
Rok vydání: 2018
Předmět:
Adult
Male
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
Croatia
Population
lcsh:Medicine
Polymorphism
genetic
Anxiety
Logistic regression
03 medical and health sciences
0302 clinical medicine
Surveys and Questionnaires
Humans
Medicine
Prospective Studies
Polymorphism
Original Scientific Papers
education
Prospective cohort study
Alleles
Neuroticism
education.field_of_study
Serotonin plasma membrane transport proteins
business.industry
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti
lcsh:R
030206 dentistry
General Medicine
Middle Aged
Healthy Volunteers
Anksioznost
Dentalna anksioznost
Polimorfizam
genetski
Serotoninski prijenosni proteini na plazmatskoj membrani
Neuroticizam
Hrvatska
Dental anxiety
Diagnostic and Statistical Manual of Mental Disorders
Social Class
Marital status
Population study
Female
Analysis of variance
genetic
medicine.symptom
business
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Acta clinica Croatica
Volume 57.
Issue 3.
Acta Clinica Croatica, Vol 57, Iss 3., Pp 417-423 (2018)
Acta Clinica Croatica
ISSN: 0353-9466
1333-9451
Popis: The aim of the study was to test the correlation between 5-HTTLPR polymorphism and dental anxiety. Research hypothesis was that positive relation between the expression of dental anxiety and the S allele exists in the population of healthy Caucasians. We conducted a prospective study on 159 subjects, volunteers made up of medical and non-medical staff of the Sestre milosrdnice University Hospital Centre. Both genders were included, age range 19 to 59, mentally and physically healthy (according to DSM-5 classification of mental disorders). For the purpose of this research, we used a sociodemographic questionnaire containing the following information: age, gender, education level, work status, marital status and residence. Corah’s Dental Anxiety Scale-Revised (DAS-R) was used to measure dental anxiety. Data distribution was tested by Kolmogorov-Smirnov test, difference between the groups by χ2-test and one-way analysis of variance, and correlation of variables by logistic regression. In the study population, we found positive correlation between S-allele and total result in DAS-R questionnaire. The presence of S allele suggests that the person will have a higher result in DAS-R questionnaire, i.e. higher expression of dental anxiety.
Cilj studije bio je ispitati povezanost polimorfizma 5-HTTLPR i dentalne anksioznosti. Naša hipoteza pretpostavlja pozitivnu povezanost izraženosti dentalne anksioznosti s S alelom u populaciji zdravih bijelaca. Provedena je prospektivna studija na 159 ispitanika, dobrovoljaca koje je sačinjavalo medicinsko i nemedicinsko osoblje KBC-a “Sestre milosrdnice”. U istraživanje su uključeni ispitanici obaju spolova, dobnog raspona od 19 do 59 godina, tjelesno i psihički zdravi (bez poremećaja prema klasifikaciji DSM-5). U istraživanju smo rabili sociodemografski upitnik sa sljedećim podacima: dob, spol, stupanj naobrazbe, radni status, bračno stanje, mjesto stanovanja. U svrhu mjerenja dentalne anksioznosti primijenjen je Corahov upitnik o dentalnoj anksioznosti (Corah Dental Anxiety Scale-Revised, DAS-R). Raspodjela podataka testirana je Kolmogorov-Smirnovljevim testom. Za testiranje razlike među skupinama primijenjen je χ2-test i jednosmjerna analiza varijance. Za utvrđivanje povezanosti među varijablama primijenjena je logistička regresija. U ispitivanoj populaciji našli smo pozitivnu povezanost S alela i ukupnog rezultata na upitniku DAS-R. Prisutnost S alela ukazuje na to da će osoba imati veći rezultat na upitniku DAS-R, odnosno veću izraženost dentalne anksioznosti.
Databáze: OpenAIRE
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