Acquired monosomy 7 in donor cells in a patient treated for acute lymphoblastic leukemia with bone marrow transplantation
| Autor: | Susanne M. Gollin, Maureen E. Sherer, Elana J. Bloom, Niel Wald, Sofia Shekhter-Levin, Steven H. Swerdlow |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research Monosomy Pathology medicine.medical_specialty Aneuploidy Biology hemic and lymphatic diseases Acute lymphocytic leukemia Genetics medicine Humans Molecular Biology Bone Marrow Transplantation Chromosome 7 (human) medicine.diagnostic_test Cytogenetics Karyotype Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease medicine.anatomical_structure Karyotyping Immunology Female Bone marrow Chromosomes Human Pair 7 Fluorescence in situ hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 95:190-197 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(96)00263-4 |
| Popis: | Two years after a bone marrow transplant (BMT) from his haploidentical mother, a 28-year-old male with a history of acute lymphoblastic leukemia (ALI.) developed myelodysplastic syndrome (MDS) with monosomy 7 in his female bone marrow cells. Follow-up cytogenetic studies, including fluorescence in situ hybridization (FISH) performed twenty-seven and thirty-one months post-BMT consistently showed a female chromosome pattern with monosomy 7. Thirty-six and thirty-nine months post-BMT, further clonal evolution occurred, with the appearance of a sideline of the female cells that first expressed a del(10)(p11.2) and then developed a translocation, t(10;21)(p11.2;q22), in addition to the monosomy 7. Cytogenetic monitoring of this male patient helped to reveal a rare case of early MDS in transplanted donor cells and evolution of the acquired abnormal clone by identifying chromosomal alterations in the donated female bone marrow cells. |
| Databáze: | OpenAIRE |
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