Statin use and Parkinson's disease in Denmark
| Autor: | Jørgen H. Olsen, Lene Wermuth, Søren Friis, Lei Qian, Eva S. Schernhammer, Beate Ritz, Angelika D. Manthripragada |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Prescription Drugs Prescription drug Statin Databases Factual medicine.drug_class Denmark Population Article Internal medicine Odds Ratio medicine Humans Outpatient clinic Registries Medical prescription education Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Parkinson Disease Retrospective cohort study Odds ratio Middle Aged medicine.disease Comorbidity Logistic Models Neurology Physical therapy Female Neurology (clinical) Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Ritz, B, Manthripragada, A D, Qian, L, Schernhammer, E, Wermuth, L, Olsen, J & Friis, S 2010, ' Statin use and Parkinson's disease in Denmark ', Movement Disorders, vol. 25, no. 9, pp. 1210-6 . https://doi.org/10.1002/mds.23102 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.23102 |
| Popis: | The objective of this study was to investigate whether statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor) use is associated with risk of Parkinson's disease (PD) in Denmark. We identified 1,931 patients with a first time diagnosis of PD reported in hospital or outpatient clinic records between 2001 and 2006. We density matched to these patients 9,651 population controls by birth year and sex relying on the Danish population register. For every participant, we identified pharmacy records of statin and anti-Parkinson drug prescriptions since 1995 and before index date from a prescription medication use database for all Danish residents. Whenever applicable, the index dates for cases and their corresponding controls were advanced to the date of first recorded prescription for anti-Parkinson drugs. In our primary analyses, we excluded all statin prescriptions 2-years before PD diagnosis. Employing logistic regression adjusting for age, sex, diagnosis of chronic obstructive pulmonary disease, and Charlson comorbidity, we observed none to slightly inverse associations between PD diagnosis and statin prescription drug use. Inverse associations with statin use were only observed for short-term ( |
| Databáze: | OpenAIRE |
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