Intravenous versus intra-arterial digital subtraction angiography: Occlusion rate and complication assessment of experimental aneurysms after flow diverter treatment in rabbits
| Autor: | Toshiki Tomori, Andreas Simgen, Christian L. Roth, Ruben Mühl-Bennighaus, Hagen Bomberg, Umut Yilmaz, Wolfgang Reith |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Carotid arteries behavioral disciplines and activities 030218 nuclear medicine & medical imaging Veins 03 medical and health sciences Random Allocation 0302 clinical medicine Aneurysm Occlusion medicine Animals Flow diverter medicine.diagnostic_test business.industry musculoskeletal neural and ocular physiology digestive oral and skin physiology Angiography Digital Subtraction Intracranial Aneurysm Digital subtraction angiography Arteries medicine.disease Cerebral Angiography Disease Models Animal Intra-arterial digital subtraction angiography Female Stents Radiology Rabbits Complication business Ligation human activities 030217 neurology & neurosurgery psychological phenomena and processes |
| Popis: | Purpose Conventional intra-arterial digital subtraction angiography, which requires surgical exposure and ligation of the femoral or carotid artery, is a limited method of evaluating elastase-induced aneurysms in New Zealand white rabbits. The purpose of this study was to assess aneurysm morphology, occlusion rates and complications after flow diverter treatment comparing intravenous and intra-arterial digital subtraction angiography. Methods We previously published a preclinical study in which we evaluated the occlusion rates of elastase-induced aneurysms after treatment with a prototype flow diverter, by using intra-arterial digital subtraction angiography at three months ( n = 9) and six months ( n = 9). In addition to that intravenous digital subtraction angiography before treatment, after one month (early follow-up group) and after three months (late follow-up group) was performed. Occlusion rates were compared within the two groups by means of residual contrast filling. Results Baseline aneurysm characteristics revealed no significant differences between intra-arterial digital subtraction angiography and intravenous digital subtraction angiography. Aneurysm occlusion rates in both follow-up groups using intravenous digital subtraction angiography were significantly higher compared to intra-arterial digital subtraction angiography (early follow-up group: intravenous digital subtraction angiography (one month) versus intra-arterial digital subtraction angiography (three months); p = 0.03 and late follow-up group: intravenous digital subtraction angiography (three months) versus intra-arterial digital subtraction angiography (six months); p = 0.04). Intravenous digital subtraction angiography is feasible to detect and reproduce device occlusions, in-stent stenosis and post-stent stenosis. Conclusion Intravenous digital subtraction angiography can not give a sufficient statement on the aneurysm occlusion process compared to intra-arterial digital subtraction angiography and is therefore not recommended for imaging follow-up after flow diverter treatment in rabbits. Regarding untreated aneurysms and complications like device occlusions, in-stent stenosis and post-stent stenosis intravenous digital subtraction angiography proofed to be a good alternative to intra-arterial digital subtraction angiography in our study. |
| Databáze: | OpenAIRE |
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