Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial beta-oxidation
| Autor: | Louis Vallée, Huguette Lafont, Gilles Nalbone, Joseph Vamecq, Christiane Van Den Branden, Renée Grataroli, Paulette Lechene de la Porte, Monique Fontaine, Dirk De Craemer |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Biophysics Biology Biochemistry Microbodies Endocrinology Internal medicine Fatty Acids Omega-6 Fatty Acids Omega-3 medicine Animals Rats Wistar Beta oxidation chemistry.chemical_classification Bile acid Myocardium Fatty acid Lipid metabolism Heart Peroxisome Fish oil Dietary Fats Mitochondria Rats chemistry Liver Fatty Acids Unsaturated Acyl-CoA Oxidase Oxidoreductases Oxidation-Reduction Corn oil Polyunsaturated fatty acid |
| Zdroj: | Biochimica et biophysica acta. 1170(2) |
| ISSN: | 0006-3002 |
| Popis: | The present work extends tissue investigations previously performed in rat gastric mucosa on lipid metabolism alterations caused by n − 3 and n − 6 fatty acid-enriched diets [13–15]. Liver and heart tissues are here studied and demonstrated to undergo, upon exposure to high fat diets with various n − 3/n − 6 fatty acid ratio contents, biochemical and morphological changes which may be enumerated as follows: (1) Rat liver peroxisomal prostaglandin E2, fatty acid but not bile acid β-oxidation rates are enhanced, especially upon the diet with the higher n − 3/n − 6 fatty acid ratio. Mitochondrial β-oxidation rates are little or not affected by the high fat diets. (2) Rat liver carnitine acyltransferases are stimulated by the high fat diets, the more rich the n − 3 fatty acid content, the more pronounced the stimulatory effect. (3) Rat heart peroxisomal and mitochondrial β-oxidation rates were increased in animals receiving the n − 3 fatty acid-enriched diet. At a low n − 3/n − 6 fatty acid ratio content of the diet, these oxidizing rate values were in control range. The carnitine acyltransferase activities were increased in rat heart to different extents, depending on the n − 3/n − 6 fatty acid ratio content of the diet. (4) Ultrastructural examination and morphometric determinations on hepatocytes from rats receiving the diets with the lowest and the highest n − 3/n − 6 fatty acid ratio contents disclose that in the latter case the numbers and fractional volumes of peroxisomes and mitochondria are significantly higher than in the former case. |
| Databáze: | OpenAIRE |
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