Hyperphosphatemia of chronic kidney disease
| Autor: | Keith A. Hruska, Ping Qiu, Raymond D. Pratt, Suresh Mathew, Richard J. Lund |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Nephrology
musculoskeletal diseases medicine.medical_specialty endocrine system diseases urologic and male genital diseases Gastroenterology Article Phosphates Hyperphosphatemia renal osteodystrophy Internal medicine medicine CKD Humans vascular smooth muscle cells Renal osteodystrophy phosphate Chronic Kidney Disease-Mineral and Bone Disorder business.industry Metabolic disorder Calcinosis nutritional and metabolic diseases osteoblasts Syndrome medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Endocrinology Cardiovascular Diseases vascular calcification Circulatory system Chronic Disease Osteoporosis Kidney Diseases business Kidney disease Blood vessel Calcification |
| Zdroj: | Kidney International. 74(2):148-157 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.2008.130 |
| Popis: | Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented. |
| Databáze: | OpenAIRE |
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