Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors
| Autor: | Kanta Mizusawa, Tatsuya Sakamoto, Perry Davis, Robert M. Dores, Akiyoshi Takahashi, Christina Reinick |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Dasyatis akajei lcsh:Computer applications to medicine. Medical informatics Melanocyte-stimulating hormone (MSH) 03 medical and health sciences Melanocortin receptor Internal medicine Stingray medicine lcsh:Science (General) Receptor Data Article Multidisciplinary integumentary system biology Chinese hamster ovary cell digestive oral and skin physiology biology.organism_classification Ligand (biochemistry) Melanocortin 3 receptor Cell biology Adrenocorticotropic hormone (ACTH) 030104 developmental biology Endocrinology lcsh:R858-859.7 Melanocortin Melanocortin receptor (MCR) hormones hormone substitutes and hormone antagonists lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 7, Iss, Pp 1670-1677 (2016) Data in Brief |
| ISSN: | 2352-3409 |
| Popis: | This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016) [1]. The amino acid sequences of the stingray, D. akajei, MC1R, MC2R, MC3R, MC4R, and MC5R were aligned with the corresponding melanocortin receptor sequences from the elephant shark, Callorhinchus milii, the dogfish, Squalus acanthias, the goldfish, Carassius auratus, and the mouse, Mus musculus. These alignments provide the basis for phylogenetic analysis of these gnathostome melanocortin receptor sequences. In addition, the Japanese stingray melanocortin receptors were separately expressed in Chinese Hamster Ovary cells, and stimulated with stingray ACTH, α-MSH, β-MSH, γ-MSH, δ-MSH, and β-endorphin. The dose response curves reveal the order of ligand selectivity for each stingray MCR. Keywords: Adrenocorticotropic hormone (ACTH), Dasyatis akajei, Melanocortin receptor (MCR), Melanocyte-stimulating hormone (MSH), Stingray |
| Databáze: | OpenAIRE |
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