Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia
| Autor: | Meei Ling Jan, Ying Kai Fu, Chih Hsien Chang, Li Chung Hwang, Kang Wei Chang, Chia Chieh Chen, Kuo Hung Wu, Chia Jung Chang, Kuan Yin Chen |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Fluorine Radioisotopes Pathology medicine.medical_specialty Rat model Cerebral arteries Ischemia 18f fdg pet Rats Sprague-Dawley Fluorodeoxyglucose F18 medicine Animals Middle cerebral artery occlusion Radiation medicine.diagnostic_test business.industry Brain Infarction Middle Cerebral Artery medicine.disease Rats Ischemic Attack Transient Positron emission tomography Positron-Emission Tomography business Metabolic activity Emission computed tomography |
| Zdroj: | Applied Radiation and Isotopes. 67:1743-1747 |
| ISSN: | 0969-8043 |
| Popis: | Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents. |
| Databáze: | OpenAIRE |
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