Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke
| Autor: | Seul Ki Min, Goo Yong Chung, Hwa Sung Shin, Hye-Jin Kim, Kyou Hee Shim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
030103 biophysics Pharmacology Neuroprotection Proinflammatory cytokine Chitosan 03 medical and health sciences chemistry.chemical_compound Ischemic brain Time windows Drug Discovery medicine Animals Cytotoxicity Stroke Liposome Chemistry Phycocyanin Infarction Middle Cerebral Artery medicine.disease Rats Disease Models Animal Neuroprotective Agents Liposomes |
| Zdroj: | Current Pharmaceutical Design. 24:1859-1864 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612824666180515123543 |
| Popis: | The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|