Melanin concentrating hormone modulates oxytocin-mediated marble burying
| Autor: | Zhiwei Wang, Olivier Civelli, Katsuhiko Nishimori, Lien Wang, Amal Alachkar, Xiangmin Xu, Nayna Sanathara, Celia Garau |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Melanin-concentrating hormone Oxytocin Repetitive behavior Marble burying chemistry.chemical_compound Mice 0302 clinical medicine Diphtheria Toxin Receptors Somatostatin Receptor Hypothalamic Hormones respiratory system Receptors Oxytocin Psychology hormones hormone substitutes and hormone antagonists medicine.drug medicine.medical_specialty Green Fluorescent Proteins Mice Transgenic Pyrimidinones Thiophenes Motor Activity Article 03 medical and health sciences Cellular and Molecular Neuroscience Mediator Internal medicine medicine Animals Maze Learning Glycoproteins Pharmacology Melanins Analysis of Variance Adaptation Ocular Oxytocin receptor Grooming Mice Inbred C57BL Luminescent Proteins Pituitary Hormones 030104 developmental biology Endocrinology chemistry Exploratory Behavior Stereotyped Behavior 030217 neurology & neurosurgery Hormone |
| Zdroj: | Neuropharmacology. 128 |
| ISSN: | 1873-7064 |
| Popis: | Repetitive and perseverative behaviors are common features of a number of neuropsychiatric diseases such as Angelman’s syndrome, Tourette’s syndrome, obsessive-compulsive disorder, and autism spectrum disorders. The oxytocin system has been linked to the regulation of repetitive behavior in both animal models and humans, but many of its downstream targets have still to be found. We report that the melanin-concentrating hormone (MCH) system is a target of the oxytocin system in regulating one repetitive behavior, marble burying. First we report that nearly 60% of MCH neurons express oxytocin receptors, and demonstrate using rabies mediated tract tracing that MCH neurons receive direct pre-synaptic input from oxytocin neurons. Then we show that MCH receptor knockout (MCHR1KO) mice and MCH ablated animals display increased marble burying response while central MCH infusion decreases it. Finally, we demonstrate the downstream role of the MCH system on oxytocin mediated marble burying by showing that central infusions of MCH and oxytocin alone or together reduce it while antagonizing the MCH system blocks oxytocin-mediated reduction of this behavior. Our findings reveal a novel role for the MCH system as a mediator of the role of oxytocin in regulating marble-burying behavior in mice. |
| Databáze: | OpenAIRE |
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