Autor: |
Anna Stoliaroff-Pepin, Caroline Peine, Tim Herath, Johannes Lachmann, Wiebke Hellenbrand, Delphine Perriat, Achim Dörre, Andreas Nitsche, Janine Michel, Marica Grossegesse, Natalie Hofmann, Thomas Rinner, Claudia Kohl, Annika Brinkmann, Tanja Meyer, Daniel Stern, Fridolin Treindl, Brigitte G. Dorner, Sascha Hein, Laura Werel, Eberhard Hildt, Sven Gläser, Helmut Schühlen, Caroline Isner, Alexander Peric, Ammar Ghouzi, Annette Reichardt, Matthias Janneck, Guntram Lock, Dominik Huster, Thomas Grünewald, Lars Schaade, Ole Wichmann, Thomas Harder |
Rok vydání: |
2023 |
Předmět: |
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Popis: |
PurposeCOViK - a prospective hospital-based multicenter case-control study in Germany - aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave.MethodsWe analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates.Results21% of cases (57/276) were not vaccinated, compared to 5% of controls (26/494; p < 0.001). Confounder-adjusted VE against COVID-19-caused hospitalization was 55.4% (95% CI: 12-78%), 81.5% (95% CI: 68-90%) and 95.6% (95%CI: 88-99%) after two, three and four vaccine doses, respectively. VE against hospitalization due to COVID-19 remained stable up to one year after three vaccine doses.ConclusionThree vaccine doses remained highly effective in preventing severe disease and this protection was sustained; a fourth dose further increased protection.Ethical review and trial registrationThe study was approved by the Ethics Committee of the Charité Universitätsmedizin, Berlin (EA1/063/21) and was registered at “Deutsches Register Klinischer Studien” (DRKS00025004).Potential conflicts of interestS. G. received payment/honoraria from Astra Zeneca, Boehringer Ingelheim, Roche Pharma, Novartis and Berlin Chemie, this had no influence on this work; all other authors reported no conflicts of interest. |
Databáze: |
OpenAIRE |
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