An apparent abnormality of the B-cell microtubular system in spiny mice (Acomys cahirinus)
| Autor: | A. Gutzeit, W. Stauffacher, M. Amherdt, Mariella Ravazzola, F. Malaisse-Lagae, Willy Malaisse, Lelio Orci |
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| Rok vydání: | 1975 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Vincristine Endocrinology Diabetes and Metabolism medicine.medical_treatment Mutant Mice Inbred Strains Biology Microtubules Islets of Langerhans Mice Species Specificity Microtubule Internal medicine Insulin Secretion Acomys cahirinus Diabetes Mellitus Internal Medicine medicine Animals Insulin B cell geography geography.geographical_feature_category Body Weight Islet Rats Mice Inbred C57BL Glucose Endocrinology medicine.anatomical_structure Ultrastructure Female medicine.drug |
| Zdroj: | Diabetologia. 11:71-76 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00422821 |
| Popis: | The pancreatic B-cell contains microtubules, which are thought to participate in the process of insulin release. In order to disclose a possible abnormaltiy of this B-cell microtubular system in animals with islet dysfunction, isolated islets from normal rats and mice, as well as from diabetic mutant mice (DBM mice) and from spiny mice (Acomys cahirinus) were incubated in the presence of vincristine, which causes the precipitation of the microtubular protein into paracrystalline deposits. Ultrastructural examination of the islets indicated that the volume-density of vincristine-induced deposits was markedly reduced in B-cells of spiny mice, when compared to that found in normal rats and mice and DBM mice. Exposure of the islets from spiny mice to a high glucose concentration, concomittantly to vincristine, caused a further reduction in vincristine-induced crystals content of the B-cell. It is speculated that an impairment of the B-cell microtubular system may account for the deficiency of insulin release found in spiny mice. |
| Databáze: | OpenAIRE |
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