The value of tumor-infiltrating lymphocytes and CD8 expression as a predictor of response to anthracycline-based neoadjuvant chemotherapy in invasive breast carcinoma of no special type
| Autor: | Berti Nelwan, Djumadi Ahmad, Upik A. Miskad, Rina Masadah, Andi Alfian Zainuddin, Halidah Rahawarin, Prihantono Prihantono, Rizki A. Rifai, Husni Cangara |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Adult Cancer Research medicine.medical_specialty Anthracycline medicine.medical_treatment Biopsy H&E stain Breast Neoplasms CD8-Positive T-Lymphocytes 03 medical and health sciences 0302 clinical medicine Breast cancer Lymphocytes Tumor-Infiltrating Predictive Value of Tests Internal medicine medicine Humans Anthracyclines Breast Aged Aged 80 and over Chemotherapy medicine.diagnostic_test business.industry Tumor-infiltrating lymphocytes General Medicine Congresses as Topic Middle Aged medicine.disease Prognosis Immunohistochemistry Neoadjuvant Therapy 030104 developmental biology 030220 oncology & carcinogenesis Histopathology Female business Mastectomy |
| Zdroj: | Breast disease. 40(S1) |
| ISSN: | 1558-1551 |
| Popis: | BACKGROUND: The immune system is known to play an important role in tumor cell eradication. Although cancer cells were able to escape from the immune system, many studies showed mononuclear inflammatory cell infiltrates known as tumor-infiltrating lymphocytes (TILs) on breast cancer histopathology specimens showed better prognosis, including in disease-free survival (DFS) and chemotherapy responses. OBJECTIVE: This study aimed to reveal the predictive value of tumor-infiltrating lymphocytes (TILs) levels and CD8 expression in invasive breast carcinoma of no special type patients’ samples on response to anthracycline-based neoadjuvant chemotherapy. METHODS: 75 pre-treatment biopsy samples that were diagnosed as invasive breast carcinoma of no special type were evaluated. TILs level determined following recommendations of International TILs Working Group 2014, CD8 expression assessed semiquantitatively after immunohistochemistry staining. Response to anthracycline-based neoadjuvant chemotherapy evaluated clinically using Response Evaluation Criteria in Solid Tumours (RECIST) criteria and pathologically by evaluating hematoxylin and eosin (H&E)-stained slides from mastectomy specimens after 3 or 4 cycles of neoadjuvant chemotherapy. RESULTS: Chi-squared analysis showed a significant relationship between TILs level and CD8 expression with chemotherapy responses clinically (p = 0.011 and p = 0.017 respectively) but not pathologically. Furthermore, the logistic regression test exhibit the predictive value of TILs level was 66.7% and CD8 expression was 64%. CONCLUSIONS: This study results suggest that TILs level and CD8 expression may be added as predictive factors to the response of anthracycline-based neoadjuvant chemotherapy, and oncologists may take benefit in breast cancer patient’s management. |
| Databáze: | OpenAIRE |
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