High Prevalence of Vitamin D Deficiency and Correlation with Cystatin-C and Other Cardiovascular and Renal Risk Biomarkers in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension
| Autor: | Khalid K. Abdul-Razzak, Mohammad J. Alkhatatbeh, Nesreen A. Saadeh, Sajedah A. Smadi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Renal function urologic and male genital diseases Gastroenterology vitamin D deficiency chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Prevalence Vitamin D and neurology medicine Humans Vitamin D Glycemic Creatinine biology business.industry Type 2 Diabetes Mellitus Vitamin D Deficiency medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Cystatin C chemistry Hypertension biology.protein business Biomarkers |
| Zdroj: | Current Diabetes Reviews. 17:81-90 |
| ISSN: | 1573-3998 |
| DOI: | 10.2174/1573399816666200516174352 |
| Popis: | Background: Vitamin D is increasingly investigated as having a role in Type 2 Diabetes Mellitus (T2DM) and its cardiovascular and renal complications. Objective: This study aimed to investigate the association between 25-hydroxyvitamin D (25-OHD) and biomarkers of cardiovascular and renal complications, including cystatin-C. Methods: This cross-sectional study involved 117 participants with T2DM that was not complicated with cardiovascular or renal diseases except hypertension. 25-OHD was measured by electrochemiluminescence immunoassay, while cystatin-C was measured by enzyme-linked-immunosorbent-assay. Other biomarkers, including lipids, creatinine, urea and glycemic measures, were determined by the routine biochemistry assays. Results: The prevalence of vitamin D deficiency was 74.36%. There was no significant difference in cardiovascular and renal biomarkers, including glucose, HbA1c, lipids, urea, creatinine and cystatin-C between participants with adequate and deficient vitamin D (p-values>0.05). Participants with adequate vitamin D were older in age, more obese and having lower eGFR (p-values0.05). Hypertensive participants were more obese, having a longer duration of DM and higher urea and cystatin-C compared to nonhypertensive participants (p-values Conclusion: 25-OHD was not found to be correlated with cardiovascular risk biomarkers, but it was correlated with renal biomarkers, including urea, creatinine and eGFR. Cystatin-C and 25-OHD were not observed to be correlated to each other, but both were correlated to renal function. Obesity was a significant predictor of hypertension. |
| Databáze: | OpenAIRE |
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