Incidence and risk factors associated with bilateral breast cancer in area with early age diagnosis but low incidence of primary breast cancer: analysis of 10-year longitudinal cohort in Taiwan
| Autor: | Tony Hsiu Hsi Chen, Po-Huang Lee, Ming-Feng Hou, Wen-Hung Kuo, King-Jen Chang, Kai Mo Chen, Amy Ming Fang Yen, Shin-Cheh Chen |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Lobular carcinoma Taiwan Breast Neoplasms Cohort Studies Breast cancer Risk Factors Internal medicine Humans Medicine Cumulative incidence Longitudinal Studies Risk factor skin and connective tissue diseases Gynecology business.industry Incidence Incidence (epidemiology) Carcinoma Ductal Breast Middle Aged medicine.disease Unilateral Breast Neoplasms Radiation therapy Carcinoma Lobular Carcinoma Intraductal Noninfiltrating Lymphatic Metastasis Invasive lobular carcinoma Female Menopause business |
| Zdroj: | Breast Cancer Research and Treatment. 99:221-228 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-006-9194-z |
| Popis: | This study aims to examine the incidence and risk factors of bilateral breast cancer in area with low incidence rate. A total of 120 and 1902 women with bilateral and unilateral breast cancers were enrolled; various factors, including those concerning their medical history and life style, were extracted. Using Kaplan-Meier method, we calculate the cumulative incidence of contralateral breast cancer. The results show as follows. The cumulative incidences of contralateral breast cancer at 1, 3, 5 years after diagnosis of first breast cancer were 1.15, 1.94, and 2.97%, respectively. The statistically significant risk factors included menopause (Hazard Ratio (HR) =1.56, (1.00-2.42)), invasive lobular carcinoma (HR=2.98, (1.35-6.56)), receiving chemotherapy (HR=2.21, (1.43-3.42)) and/or radiotherapy (HR=3.32, (2.19-5.05) and a protective factor was tamoxifen therapy (HR=0.5 (0.34-0.74). Size of the second occurred tumour (2.97 cm) tended to be smaller than the first one (3.58 cm) with borderline statistical significance (p=0.0731). Comparing to the existing data on Western countries, we find a higher risk for developing contralateral breast cancer in Taiwan where a low incidence of first breast cancer rate with early age diagnosis is noted. It suggests that first primary breast tumour with early age of onset and lobular carcinoma are found more likely to develop bilateral breast cancers. |
| Databáze: | OpenAIRE |
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