Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

Autor: Nancy J. Rothwell, Andy Vail, Elisa M. Barberan, John M. Hallenbeck, Hedley C. A. Emsley, Gregory J. del Zoppo, Carole M. Gavin, Stephen J. Hopkins, Pippa J. Tyrrell, Rachel Georgiou, Craig J. Smith
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Male
Pathology
Neurology
Hydrocortisone
Severity of Illness Index
lcsh:RC346-429
Body Temperature
Brain Ischemia
Brain ischemia
stroke acute
Leukocyte Count
0302 clinical medicine
Prospective Studies
Prospective cohort study
Stroke
0303 health sciences
biology
General Medicine
Peripheral
Survival Rate
Cardiology
Disease Progression
Female
medicine.drug
Research Article
Brain Infarction
medicine.medical_specialty
Clinical Neurology
Blood Sedimentation
C-reactive protein
03 medical and health sciences
outcome measures
Predictive Value of Tests
Internal medicine
Severity of illness
medicine
Humans
cardiovascular diseases
lcsh:Neurology. Diseases of the nervous system
030304 developmental biology
Aged
business.industry
interleukin-6
medicine.disease
inflammation
biology.protein
Neurology (clinical)
business
Tomography
X-Ray Computed
030217 neurology & neurosurgery
Biomarkers
Zdroj: BMC Neurology, Vol 4, Iss 1, p 2 (2004)
BMC Neurology
ISSN: 1471-2377
Popis: Background Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results Peak plasma IL-6 concentration correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma C-reactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.
Databáze: OpenAIRE
Externí odkaz: