Natural cytotoxicity in rats: Strain distribution and genetics
| Autor: | G A Gutman, M R Heyworth, L J McNeilage, Barbara F. Heslop |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cytotoxicity
Immunologic Male Genetic Linkage Lymphocyte Immunology Population Biology Major histocompatibility complex Species Specificity Histocompatibility Antigens medicine Animals Lymphocytes Cytotoxicity education Lymph node Crosses Genetic Genetics education.field_of_study Strain (chemistry) Rats Inbred Strains Immunity Innate Rats Inbred F344 Allotype Rats medicine.anatomical_structure Rats Inbred Lew Lymphocyte Transfusion biology.protein Female Lymph Nodes Lymph |
| Zdroj: | Cellular Immunology. 72:340-350 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(82)90482-8 |
| Popis: | The term natural cytotoxicity (NC) describes a phenomenon in rats whereby significant numbers of intravenously injected 51 Cr-labeled lymph node cells are rapidly destroyed by unsensitized allogeneic hosts. Cell death is reflected in a decreased accumulation of labeled cells in the host lymph nodes, with a corresponding increase in the label excreted by the kidney. Natural cytotoxicity has been studied in 95 allogeneic donor-host combinations among inbred rats and in a segregating population of F1 backcross animals. On the basis of lymphocyte distribution patterns, the individual donor-host combinations have been categorized as exhibiting high NC (13 strain combinations), intermediate NC (63 strain combinations), or low NC (19 strain combinations). Analysis of the segregating F1 backcross population showed NC to be controlled by at least two independently segregating genes, one of which was linked to the MHC, and the other of which was possibly, but by no means certainly, X linked. No linkage was demonstrated with respect to coat color loci (C, A, H) or to kappa chain allotype (RI-1). Natural cytotoxicity appears to belong to a group of several phenomena characterized by the rapid destruction of allogeneic cells by apparently unsensitized hosts. |
| Databáze: | OpenAIRE |
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