Erythropoietin Resistance in Hemodialysis Patients
| Autor: | Sasa Jacovic, Nedim Hamzagić, Milena Jovanović, Dejan Petrovic, Radisa Pavlovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
hemodialysis business.industry medicine.medical_treatment vitamin D deficiency vitamin D eficiency lcsh:R 030232 urology & nephrology lcsh:Medicine General Medicine 030204 cardiovascular system & hematology anemia 3. Good health erythropoietin resistance 03 medical and health sciences 0302 clinical medicine Erythropoietin microinflammation Internal medicine hemic and lymphatic diseases medicine Hemodialysis business medicine.drug |
| Zdroj: | Acta Facultatis Medicae Naissensis, Vol 36, Iss 1, Pp 5-14 (2019) Acta Facultatis Medicae Naissensis (2019) 36(1):5-14 |
| ISSN: | 2217-2521 0351-6083 |
| Popis: | Summary Anemia is defined as blood hemoglobin concentration of less than 120 g/l in women and less than 130 g/l in men. The main cause of the development of anemia in patients treated with regular hemodialysis is the lack of endogenous erythropoietin, and its main clinical consequences are: progressive decline in residual renal function, development of cardiovascular disorders, disorders of cognitive functions and a decrease in the quality of life of these patients. Despite the administration of an appropriate dose of erythropoietin, in 5-10% of patients treated with regular hemodialysis, there is resistance to erythropoietin activity. The main risk factors for the development of resistance to the effects of erythropoietin are: iron deficiency, microinflammation, deficiency of vitamin D, secondary hyperparathyroidism, deficiency of vitamin C, and inadequate hemodialysis. The main side effects of erythropoietin are: hypertension, thrombosis of the vascular approach to hemodialysis, and the red blood cell precursor aplasia in the bone marrow. Early detection and elimination of risk factors, optimization and indi-vidualization of hemodialysis prescription prevent the development of resistance to erythropoietin activity, enable the achievement of target blood hemoglobin, reduce the development of cardiovascular morbidity, and improve the quality of life of these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|