Exosomes: a novel therapeutic target for Alzheimer’s disease?
| Autor: | Ming Xiao, Zun-Yu Ke, Sohel H. Quazi, Zhiyou Cai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Review medicine.disease_cause Exosome lcsh:RC346-429 neuroinflammation Pathogenesis 03 medical and health sciences nerve regeneration microvesicle beta-amyloid tau oxidative stress therapeutic target neurodegeneration dementia neural regeneration 0302 clinical medicine Developmental Neuroscience medicine Extracellular Neuroinflammation lcsh:Neurology. Diseases of the nervous system Chemistry Microvesicle Neurodegeneration medicine.disease Microvesicles Cell biology 030104 developmental biology 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Neural Regeneration Research, Vol 13, Iss 5, Pp 930-935 (2018) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as multivesicular bodies. Thus, exosomes contain cytoplasmic content. Multivesicular bodies fuse with the plasma membrane and release exosomes into the extracellular environment. Comprehensive research suggests that exosomes act as both inflammatory intermediaries and critical inducers of oxidative stress to drive progression of Alzheimer's disease. An important role of exosomes in Alzheimer's disease includes the formation of neurofibrillary tangles and beta-amyloid production, clearance, and accumulation. In addition, exosomes are involved in neuroinflammation and oxidative stress, which both act as triggers for beta-amyloid pathogenesis and tau hyperphosphorylation. Further, it has been shown that exosomes are strongly associated with beta-amyloid clearance. Thus, effective measures for regulating exosome metabolism may be novel drug targets for Alzheimer's disease. |
| Databáze: | OpenAIRE |
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